{"term":{"id":"09784","title":"targeted proteomics","longtitle":"IUPAC Gold Book - targeted proteomics","doi":"10.1351\/goldbook.09784","code":"09784","status":"current","mentioned":"<em>mentioned<\/em>: multiple reaction monitoring (MRM), selected reaction monitoring (SRM)","definitions":[{"id":1,"text":"Approach in proteomics focused on the selected proteins of a sample.","notes":{"1":"In a targeted analysis, the mass spectrometer is programmed to analyse a preselected group of proteins. This can be achieved using a technology called selected reaction monitoring (SRM; also referred to as multiple reaction monitoring, MRM), whereby assays are developed on a triple quadrupole instrument to detect fragment-ion signals arising from unique diagnostic peptides representing each of the targeted proteins.","2":"Targeted proteomics achieves the highest sensitivity and throughput for hundreds or thousands of samples in regard to the intended aspect (namely target fragments)."},"links":[{"term":"proteomics","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/09780"}],"sources":["PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1164 (https:\/\/doi.org\/10.1515\/pac-2016-1120)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/09784\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/09784\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/09784\/plain"},"citation":"Citation: 'targeted proteomics' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.09784","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-08T09:41:19+00:00"}}