{"term":{"id":"09782","title":"stable isotope labelling","longtitle":"IUPAC Gold Book - stable isotope labelling","doi":"10.1351\/goldbook.09782","code":"09782","status":"current","definitions":[{"id":1,"text":"Techniques which serve to quantify protein content by means of mass spectrometry. The principle lies in the introduction of a mass tag to an internal standard protein\/peptide containing different stable isotopes than the protein\/peptide in the sample. Mass resolved signals originating in the internal standard and the sample are read individually and evaluated.","notes":{"1":"In the case of a complex sample, the use of multiple reaction monitoring allows for the resolution of multiple overlapping signals."},"contexts":[],"sources":["PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1164 (https:\/\/doi.org\/10.1515\/pac-2016-1120)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/09782\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/09782\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/09782\/plain"},"citation":"Citation: 'stable isotope labelling' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.09782","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-01T09:56:17+00:00"}}