Ion fragmentation technique in mass spectrometry-driven proteomics that is a combination of electron-transfer dissociation (ETD) and higher-energy collision dissociation (HCD) in Kingdon trap instruments (Orbitrap™).
Note: The dual fragmentation allows generation of rich MS/MS spectra for peptide sequencing and post-translational modification (PTM) analysis.
Source:
PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1155 (https://doi.org/10.1515/pac-2016-1120)