{"term":{"id":"09709","title":"nucleic acid aptamers","longtitle":"IUPAC Gold Book - nucleic acid aptamers","doi":"10.1351\/goldbook.09709","code":"09709","status":"current","mentioned":"<em>mentioned<\/em>: systematic evolution of ligands by exponential enrichment (SELEX)","definitions":[{"id":1,"text":"Single stranded (ss) oligonucleotides (mainly deoxyribonucleic acid (DNA) or ribonucleic acid (RNA)) originating from in vitro selection, which, starting from random sequence libraries, optimise the nucleic acids for high-affinity binding to a given target.","notes":{"1":"In vitro selection is an iterative method mainly known as Systematic Evolution of Ligands by EXponential enrichment (SELEX)."},"sources":["PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1148 (https:\/\/doi.org\/10.1515\/pac-2016-1120)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/09709\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/09709\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/09709\/plain"},"citation":"Citation: 'nucleic acid aptamers' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.09709","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-28T13:02:14+00:00"}}