{"term":{"id":"09680","title":"monoclonal","longtitle":"IUPAC Gold Book - monoclonal","doi":"10.1351\/goldbook.09680","code":"09680","status":"current","definitions":[{"id":1,"text":"Arising from a single clone of cells.","notes":{"1":"In the case of immunoglobulin, \"monoclonal\" refers to its origin.","2":"Usually, the monoclonal antibody is of a single immunoglobulin class containing only one light chain type of either the K or L variety. It also refers to all antibody molecules having identical physical-chemical characteristics and antibody specificity. Monoclonal antibodies have very restricted structural diversity and they are homogeneous compared with polyclonal antibodies."},"sources":["PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1141 (https:\/\/doi.org\/10.1515\/pac-2016-1120)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/09680\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/09680\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/09680\/plain"},"citation":"Citation: 'monoclonal' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.09680","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-08-03T23:07:46+00:00"}}