Title: total correlation spectroscopy
Long Title: IUPAC Gold Book - total correlation spectroscopy
DOI: 10.1351/goldbook.08435
Status: current

Definition
Two-dimensional nuclear magnetic resonance homonuclear correlation experiment, which creates correlations between all protons within a given spin system, not just between geminal or vicinal protons as in COSY.

Note
TOCSY uses a spin lock to allow propagation of magnetization through scalar couplings.

Related Terms
- COSY: https://goldbook.iupac.org//terms/view/08323
- Two-dimensional nuclear magnetic resonance: https://goldbook.iupac.org//terms/view/08439
- spin system: https://goldbook.iupac.org//terms/view/08421

Source
- PAC, 2021, 93, 647. 'Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)' on page 709 (https://doi.org/10.1515/pac-2019-0203)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/08435/html
- json: https://goldbook.iupac.org/terms/view/08435/json
- xml: https://goldbook.iupac.org/terms/view/08435/xml

Citation: Citation: 'total correlation spectroscopy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.08435
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Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-07-26T09:43:37+00:00