Title: diffusion ordered spectroscopy
Long Title: IUPAC Gold Book - diffusion ordered spectroscopy
DOI: 10.1351/goldbook.08329
Status: current

Definition
Pseudo-two-dimensional nuclear magnetic resonance spectroscopy experiment that resolves NMR signals of a one-dimensional nuclear magnetic resonance spectrum in a second dimension through the diffusion times of their corresponding molecules.

Notes
1) DOSY is used to differentiate signals from different molecules based on their effective sizes.
2) DOSY relies on spatially encoding the analyte by use of pulsed-field gradients.

Related Terms
- nuclear magnetic resonance spectrum: https://goldbook.iupac.org//terms/view/08384
- pulsed-field gradients: https://goldbook.iupac.org//terms/view/08397
- two-dimensional nuclear magnetic resonance spectroscopy: https://goldbook.iupac.org//terms/view/08439

Source
- PAC, 2021, 93, 647. 'Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)' on page 685 (https://doi.org/10.1515/pac-2019-0203)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/08329/html
- json: https://goldbook.iupac.org/terms/view/08329/json
- xml: https://goldbook.iupac.org/terms/view/08329/xml

Citation: Citation: 'diffusion ordered spectroscopy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.08329
License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.
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Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-07-26T00:01:27+00:00